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    描述
    English: ==The P450 catalytic cycle==

    1: The substrate binds to the active site of the enzyme, in close proximity to the heme group, on the side opposite to the peptide chain. The bound substrate induces a change in the conformation of the active site, displacing a water molecule from the distal axial coordination position of the heme iron[1] changing the state of the heme iron from low-spin to high-spin[2]. This gives rise to a change in the spectral properties of the enzyme, with an increase in absorbance at 390~nm and a decrease at 420~nm. This can be measured by difference spectrometry and is referred to as the "type~I" difference spectrum (see inset graph in figure). Some substrates cause an opposite change in spectral properties, a "reverse type~I" spectrum, by processes that are as yet unclear. Inhibitors and certain substrates that bind directly to the heme iron give rise to the type~II difference spectrum, with a maximum at 430~nm and a minimum at 390~nm (see inset graph in figure). If no reducing equivalents are available, this complex remains stable, allowing the degree of binding to be determined from absorbance measurements in vitro[3]

    2: The change in the electronic state of the active site favours the transfer of an electron from NAD(P)H[4]. This takes place via the electron transfer chain, as described above, reducing the ferric heme iron to the ferrous state.

    3: Molecular oxygen binds covalently to the distal axial coordination position of the heme iron. The cysteine ligand is a better electron donor than histidine, with the oxygen consequently being activated to a greater extent than in other heme proteins. However, this sometimes allows the bond to dissociate, the so-called "decoupling reaction", releasing a reactive superoxide radical, interrupting the catalytic cycle[1].

    4: A second electron is transferred via the electron-transport system, reducing the dioxygen adduct to a negatively charged peroxo group. This is a short-lived intermediate state.

    5: The peroxo group formed in step 4 is rapidly protonated twice by local transfer from surrounding amino-acid side chains, releasing one mole of water, and forming a highly reactive iron(V)-oxo species[1].

    6: Depending on the substrate and enzyme involved, P450 enzymes can catalyse any of a wide variety of reactions. A hypothetical hydroxylation is shown in this illustration. After the product has been released from the active site, the enzyme returns to its original state, with a water molecule returning to occupy the distal coordination position of the iron nucleus. S An alternative route for mono-oxygenation is via the "peroxide shunt": interaction with single-oxygen donors such as peroxides and hypochlorites can lead directly to the formation of the iron-oxo intermediate, allowing the catalytic cycle to be completed without going through steps 3, 4 and 5[3]. A hypothetical peroxide "XOOH" is shown in the diagram.

    C: If carbon monoxide (CO) binds to reduced P450, the catalytic cycle is interrupted. This reaction yields the classic CO difference spectrum with a maximum at 450 nm.

    1. ↑ a b c Bernard Meunier, Samuël P. de Visser and Sason Shaik (2004). "Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes". Chemical Reviews 104 (9): 3947 - 3980.
    2. ↑ Thomas L. Poulos, Barry C. Finzel and Andrew J. Howard (1987). "High-resolution crystal structure of cytochrome P450cam". Journal of Molecular Biology 195 (3): 687-700.
    3. ↑ a b P.R. Ortiz de Montellano (Ed.) (1995年) 《 Cytochrome P450 : structure, mechanism, and biochemistry, 2nd ed.》、Category:New York: Plenum
    4. ↑ S. G. Sligar, D. L. Cinti, G. G. Gibson and J. B. Schenkman (1979). "Spin state control of the hepatic cytochrome P450 redox potential". Biochemical and Biophysical Research Communications 90 (3): 925-932.
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    來源 M.Sc. Thesis, David Richfield (User:Slashme)
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    英文維基百科的Slashme When using this image in external works, it may be cited as follows:

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    目前2012年4月22日 (日) 15:07於 2012年4月22日 (日) 15:07 版本的縮圖9,240 × 6,968​(38 KB)Slashme{{Information |Description ={{en|1====The P450 catalytic cycle== 1: The substrate binds to the active site of the enzyme, in close proximity to the heme group, on the side opposite to the peptide chain. The bound substrate induces a change in the ...
    2012年4月22日 (日) 14:49沒有縮圖9,240 × 6,968​(38 KB)SlashmeCorrected peroxide shunt arrow.
    2008年7月5日 (六) 10:34於 2008年7月5日 (六) 10:34 版本的縮圖9,240 × 6,968​(35 KB)Slashme{{Information |Description={{en|1===The P450 catalytic cycle== 1: The substrate binds to the active site of the enzyme, in close proximity to the heme group, on the side opposite to the peptide chain. The bound substrate induces a change in the conforma

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