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HDAC1

本页使用了标题或全文手工转换
维基百科，自由的百科全书
HDAC1
已知的结构
PDB直系同源搜索：PDBe RCSB
标识符
代号HDAC1
扩展标识OMIM：601241；MGI：108086；HomoloGene：68426；GeneCards：HDAC1；OMA：HDAC1 - orthologs
EC编号3.5.1.98
直系同源
物種人類小鼠
Entrez
3065
433759
Ensembl
ENSG00000116478
ENSMUSG00000028800
UniProt
Q13547
O09106
mRNA序列
​NM_004964
NM_008228
蛋白序列
NP_004955
NP_032254
基因位置Chr 1：32.29 – 32.33 MbChr 4：129.41 – 129.44 Mb
PubMed查询[3][4]
维基数据
檢視/編輯人類檢視/編輯小鼠

組蛋白去乙醯酶1（英語：Histone deacetylase 1，HDAC1）是一種酶，在人類中由HDAC1基因編碼。[5]

功能

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組蛋白乙醯化與去乙醯化由多亞基複合物催化，在調節真核生物基因表達中發揮關鍵作用。此基因編碼的蛋白質屬於組蛋白去乙醯酶/acuc/apha家族，是組蛋白去乙醯酶複合物的組成部分。它亦與視網膜母細胞瘤腫瘤抑制蛋白相互作用，該複合物是控制細胞增殖和分化的關鍵元素。與MTA2一起，可去乙醯化p53並調節其對細胞生長和凋亡的影響。[6]

交互

[编辑]

已证实HDAC1可与以下蛋白交互： 

参见

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参考文獻

[编辑]
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