MAP3K7IP2
关于金屬化合物TaB2，请见「硼化钽」。
促分裂原活化蛋白激酶激酶激酶7相互作用蛋白2（英語：Mitogen-activated protein kinase kinase kinase 7-interacting protein 2，簡稱MAP3K7IP2）是一種酶，在人類中由MAP3K7IP2基因編碼。[5][6][7]
該基因編碼的蛋白質是MAP3K7/TAK1的激活劑，為IL-1誘導的核因子κB（NF-κB）及激活MAPK8/JNK所必需。此蛋白與TRAF6、MAP3K7及TAB1形成激酶複合物，作為連接MAP3K7與TRAF6的接合蛋白。 MAP3K7IP2、TAB1及MAP3K7亦參與由TNFSF11/RANKL誘導的信號轉導，透過激活NF-κB受體激活劑（TNFRSF11A/RANK），可調節破骨細胞的發育與功能。[7]
MAP3K7IP2突變與人類先天性心臟缺陷有關。研究發現，TAB2（即MAP3K7IP2）單倍體不足可導致多種先天性心臟缺陷，包括二尖瓣及三尖瓣脫垂、主動脈狹窄等，部分患者可能面臨猝死風險。[8][9]
交互作用
[编辑]MAP3K7IP2與以下物质交互：
参考文獻
[编辑]- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000055208 – Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000015755 – Ensembl, 2017年5月
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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.
- ^ 6.0 6.1 6.2 6.3 6.4 Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. Jul 2000, 5 (4): 649–58. PMID 10882101. doi:10.1016/S1097-2765(00)80244-0 .
- ^ 7.0 7.1 Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2.
- ^ Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent LC, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K, Larsen LA. Haploinsufficiency of TAB2 causes congenital heart defects in humans.. Am J Hum Genet. 2010, 86 (6): 839–49. PMC 3032066 . PMID 20493459. doi:10.1016/j.ajhg.2010.04.011.
- ^ TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2026-08-01].
- ^ 10.0 10.1 10.2 Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell. Jul 2002, 110 (1): 55–67. PMID 12150997. S2CID 17679498. doi:10.1016/S0092-8674(02)00809-7 .
- ^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. Feb 2004, 6 (2): 97–105. PMID 14743216. S2CID 11683986. doi:10.1038/ncb1086.
- ^ 12.0 12.1 Cheung PC, Nebreda AR, Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. Feb 2004, 378 (Pt 1): 27–34. PMC 1223947 . PMID 14670075. doi:10.1042/BJ20031794.
- ^ 13.0 13.1 Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. Dec 2003, 22 (23): 6277–88. PMC 291846 . PMID 14633987. doi:10.1093/emboj/cdg605.
- ^ 14.0 14.1 Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K. Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol. Cell. Biol. Apr 2001, 21 (7): 2475–84. PMC 86880 . PMID 11259596. doi:10.1128/MCB.21.7.2475-2484.2001.
- ^ 15.0 15.1 Ma Q, Zhou L, Shi H, Huo K. NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Cell. Signal. Jun 2008, 20 (6): 1044–51. PMID 18299187. doi:10.1016/j.cellsig.2008.01.015.
- ^ Li S, Wang L, Dorf ME. PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. Mol. Cell. Jan 2009, 33 (1): 30–42. PMC 2643372 . PMID 19150425. doi:10.1016/j.molcel.2008.11.023.
- ^ Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y. Unutmaz D , 编. TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLOS ONE. 2008, 3 (12). Bibcode:2008PLoSO...3.4064W. PMC 2603309 . PMID 19112497. doi:10.1371/journal.pone.0004064 . 已忽略未知参数
|article-number=(帮助) - ^ Windheim M, Stafford M, Peggie M, Cohen P. Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase. Mol. Cell. Biol. Mar 2008, 28 (5): 1783–91. PMC 2258775 . PMID 18180283. doi:10.1128/MCB.02380-06.
延伸阅读
[编辑]- Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2003, 9 (3): 99–106. PMID 12168954. doi:10.1093/dnares/9.3.99 .
- Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996, 272 (5265): 1179–82. Bibcode:1996Sci...272.1179S. PMID 8638164. S2CID 84807994. doi:10.1126/science.272.5265.1179.
- Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K. Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol. Cell. Biol. 2001, 21 (7): 2475–84. PMC 86880 . PMID 11259596. doi:10.1128/MCB.21.7.2475-2484.2001.
- Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J. Biol. Chem. 2001, 276 (45): 41661–7. PMID 11518704. doi:10.1074/jbc.M102262200 .
- Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N. Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell. Biol. 2002, 22 (4): 992–1000. PMC 134634 . PMID 11809792. doi:10.1128/MCB.22.4.992-1000.2002.
- Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. J. Biol. Chem. 2002, 277 (34): 30454–62. PMID 12048196. doi:10.1074/jbc.M203312200 .
- Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell. 2002, 110 (1): 55–67. PMID 12150997. S2CID 17679498. doi:10.1016/S0092-8674(02)00809-7 .
- Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X. Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol. Cell. Biol. 2002, 22 (20): 7158–67. PMC 139807 . PMID 12242293. doi:10.1128/MCB.22.20.7158-7167.2002.
- Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J. Biol. Chem. 2003, 278 (19): 16713–9. PMID 12609980. doi:10.1074/jbc.M300562200 .
- Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. 2003, 22 (21): 3307–18. PMID 12761501. S2CID 38880905. doi:10.1038/sj.onc.1206406.
- Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 2004, 22 (23): 6277–88. PMC 291846 . PMID 14633987. doi:10.1093/emboj/cdg605.
- Cheung PC, Nebreda AR, Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. 2004, 378 (Pt 1): 27–34. PMC 1223947 . PMID 14670075. doi:10.1042/BJ20031794.
- Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. 2004, 6 (2): 97–105. PMID 14743216. S2CID 11683986. doi:10.1038/ncb1086.
- Owerbach D, Piña L, Gabbay KH. A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes. Diabetes. 2004, 53 (7): 1890–3. PMID 15220215. doi:10.2337/diabetes.53.7.1890 .
- Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol. Cell. 2004, 15 (4): 535–48. PMID 15327770. doi:10.1016/j.molcel.2004.08.008 .