Upjohn

The Upjohn Company
The Upjohn Company
公司類型	公司
公司結局	與Pharmacia合併為Pharmacia & Upjohn
後繼機構	Pharmacia & Upjohn; 暉致（Viatris）
成立	1886年
結束	1995年，31年前
總部	美國密歇根州波蒂奇
產業	製藥產業

Upjohn是一家美國製藥公司，1886年由威廉·E·厄普約翰在密歇根州黑斯廷斯成立^[1]，1995年與瑞典Pharmacia公司合併為Pharmacia & Upjohn，現為輝瑞公司所有。

歷史

1976年，公司的三位科學家開發了Upjohn雙羥基化反應^[2]。

產品

四位數

名稱	CAS號	分子式
苄非他明（U-0441）	156-08-1	C 17H 21N
U-0882	310-35-0	C 18H 21NO 2
敵鼠（U-1363）	82-66-6	C 23H 16O 3
羧雌醚（U-2911）	1755-52-8	C 17H 22O 3
放線菌酮（U-4527）	66-81-9	C 15H 23NO 4
菲律賓菌素III （U-5956）	480-49-9	C 35H 58O 11
氟甲睾酮（U-6040）	76-43-7	C 20H 29FO 3
N,N-二甲基高色胺（U-6056）	13117-35-6	C 13H 18N 2
U-8113	1688-71-7	C 10H 13NO
尿嘧啶氮芥（U-8344）	66-75-1	C 8H 11Cl 2N 3O 2
甲羥松（U-8471）	2668-66-8	C 22H 32O 3
‌氟米龍（U-8614）	426-13-1	C 22H 29FO 4
醋酸甲羥孕酮（U-8839）	71-58-9	C 24H 34O 4
甲羥孕酮（U-8840）	520-85-4	C 22H 32O 3
2-氨基-1,1,3-三氰基-1-丙烯（U-9189）	868-54-2	C 6H 4N 4
鏈脲素（U-9889）	18883-66-4	C 8H 15N 3O 7

五位數

名稱	CAS號	分子式
林可黴素（U-10149）	154-21-2	C 18H 34N 2O 6S
U-10029A	89139-29-7	C 17H 18F 3NO 2
U-10157	705-62-4	C 9H 12N 2S
米勃龍（U-10997）^[3]	3704-09-4	C 20H 30O 2
U-11000A	1845-11-0	C 29H 31NO 2
U-11555A	64-96-0	C 28H 31NO 2
曲托龍（U-11828）^[3]	3764-87-2	C 19H 28O 2
U-12504	1228-19-9	C 13H 18ClN 3O 3S
U-14462	1034-82-8	C 15H 22N 2O 3S
U-17312E	2235-90-7	C 12H 16N 2
U-17323	3801-06-7	C 24H 31FO 5
U-17660	13450-72-1	C 18H 21N 3O
U-17835	1156-19-0	C 14H 21N 3O 3S
布洛芬（U-18573）	15687-27-1	C 13H 18O 2
U18666A	3039-71-2	C 25H 41NO 2
U-19052	112682-32-3	C 31H 42O 6S
卡拉芬淨（U-19718）	11048-15-0	C 16H 12O 6
勃拉睾酮（U-19763）	1605-89-6	C 21H 32O 2
吲哚克索（維基數據：Q27286852）（U-22020）	5034-76-4	C 22H 19NO 2
PNU-22394 (U-22394A)	15923-78-1	C 13H 16N 2
U-22410A	10090-61-6	C 28H 29NO
卡魯睾酮（U-22550）	17021-26-0	C 21H 32O 2
U-23284	18771-50-1	C 9H 16N 2O 6
U-23469^[4]	36840-93-4	C 26H 28O 4
U-24568	21766-17-6	C 26H 22N 2O 2
美利曲辛 (U-24973A)	10563-70-9	C 21H 25N
U-26384	112646-88-5	C 25H 42N 2O
U-26597A	8001-95-4	C 11H 28ClN 5O
U-27391	106314-87-8	C 23H 36N 4O 5
U-28288D	22195-34-2	C 10H 19N 3O 2
2-MDP （U-23807A）	33887-05-7	C 16H 19NO
U-28774	27223-35-4	C 20H 17ClN 2O 3
U-29409	31785-60-1	C 18H 14N 2O
U-30870	50303-11-2	C 23H 31NO 2
U-31355	99983-92-3	C 11H 10ClN 3S
阿普唑侖（U-31889）	28981-97-7	C 17H 13ClN 4
骨化二醇（U-32070）	19356-17-3	C 27H 44O 2
U-32802A	36735-48-5	C 22H 23F 2NO
三唑侖（U-33030）	28911-01-5	C 17H 12Cl 2N 4
U-35777A	55199-71-8	C 23H 27F 2NO 2
U-37883A	57568-80-6	C 21H 35N 3O
U-41792	56714-70-6	C 21H 29NO
U-42585	53882-12-5	C 11H 6ClN 3O 6
U-43795	54549-02-9	C 5H 7ClN 2O 4
U-46619	56985-40-1	C 21H 34O 4
U-46785	61263-35-2	C 23H 38O 4
U-47109	67579-13-9	C 15H 20Cl 2N 2O
U-47476A	36192-18-4	C 12H 18N 2
U-47700	82657-23-6	C 16H 22Cl 2N 2O
溴朵林（U-47931E）	67579-24-2	C₁₅H₂₁BrN₂O
U-48520	67579-11-7	C 16H 23ClN 2O
依氯那明（U-48753）	67450-44-6	C 16H 22Cl 2N 2O
U-48800	2370977-17-4	C 17H 24Cl 2N 2O
U-49900	67579-76-4	C 18H 26Cl 2N 2O
U-50211	98587-47-4	C 16H 24N 2O 2
U-50488	67198-13-4	C 19H 26Cl 2N 2O
U-51574	PubChem CID：44269303	C 17H 24Cl 2N 2O
U-52047	71628-96-1	C 28H 31NO 10
U-53059	70529-35-0	C 18H 14F 3NO 2S
U-54669F	72141-57-2	C 27H 22F 4N 4O 3S
U-56407	87695-80-5	C 29H 32N 2O 7
U-57700	102092-12-6	C 16H 21N
U-57930E	79548-73-5	C 17H 31ClN 2O 5S
U-58838	83701-22-8	C 9H 15N 5O 4S
吡前列素（維基數據：Q27287941）（U-60257）	79672-88-1	C 26H 35NO 4
U-61431F	81845-44-5	C 22H 36O 4
螺朵林（英語：Spiradoline）（U-62066）	87151-85-7	C 22H 30Cl 2N 2O 2
U-62162	82516-67-4	C 23H 33NO 6
U-63366	88669-04-9	C 17H 30N 2O 7
呋格雷酸（U-63557A）	85666-24-6	C 15H 11NO 3
U-64279E	104010-37-9	C 19H 17N 5O 7S 3
阿侖替莫（U-66444B）	112892-81-6	C 19H 25NO
U-68415	104713-40-8	C 30H 23N 5O 3
U-69167	99499-40-8	C 16H 17N 3OS 2
U-69593	96744-75-1	C 22H 32N 2O 2
U-70714E	114376-16-8	C 66H 76N 12O 10
U-71184	101222-80-4	C 30H 23N 5O 3
U-71185	104713-39-5	C 30H 23N 5O 3
U-73122	112648-68-7	C 29H 40N 2O 3
U-73343	142878-12-4	C 29H 42N 2O 3
U-74006	110101-66-1	C 38H 52N 6O 2
U-75302（維基數據：Q27089045）	119477-85-9	C 22H 33NO 3
U-75799E	87616-84-0	C 46H 56N 12O 6
U-75875 （Pnu-75875）	112190-24-6	C 45H 61N 7O 7
U-76073	119813-16-0	C 34H 32ClN 5O 4
U-76074	119813-15-9	C 34H 31N 5O 4
U-77436	128657-36-3	C 50H 76N 10O 11
U-77803	118625-40-4	C 33H 46N 2O 17S 2
U-77863	146669-23-0	C 10H 11NO
U-77864	146669-24-1	C 10H 13NO 2
U-77891	119878-31-8	C 18H 24Br 2N 2O
U-78036	123742-98-3	C 17H 11ClN 2O
U-78608	123444-35-9	C 21H 22N 10O 11S 2
U-78875	124423-84-3	C 18H 17N 5O 2
卡折來新（維基數據：Q27263977）（U-80244）	119813-10-4	C 41H 37ClN 6O 5
U-80493	136816-67-6	C 21H 30N 4O
U-81749	126103-94-4	C 33H 56N 4O 4
U-82208E	136591-56-5	C 20H 36N 2O 3S
U-82209E	136591-58-7	C 20H 36N 2O 3S
U-84569	130736-25-3	C 25H 23NO 4
U-86983	130736-65-1	C 19H 18N 2O 4
阿替韋啶（U-87201E）	138540-32-6	C 21H 25N 5O 2
U-88779E	149539-01-5	C 29H 33ClN 2O 2
U88999E	142223-57-2	C 29H 32F 2N 2O 2
U-89232	134017-78-0	C 19H 25N 5O 2
U-89360E	161897-65-0	C 28H 52N 8O 6
U-90152	136817-59-9	C 22H 28N 6O 3S
PNU-91356A （U-91356）	152886-85-6	C 13H 17N 3O
U-92032	142223-92-5	C 30H 35F 2N 3O 2
U-92163	149607-21-6	C 34H 51N 5O 5
U-92798	PC9891838	C 30H 34F 2N 2O 2
U-96415E （PNU 96415E）	170856-41-4	C 21H 27Cl 2FN 2O
U-96988	149394-65-0	C 24H 26O 3
伊他司瓊（英語：Itasetron）（U-98097）	123258-84-4	C 16H 20N 4O 2
普拉克索（U-98528E）	104632-26-0	C 10H 17N 3S
JPC-211 （U-99194）	82668-33-5	C 17H 27NO 2
U-99363	179556-82-2	C 20H 27N 3O
U-99751	171858-84-7	C 16H 20BrN 3O 2

六位數

名稱	CAS號	分子式
U-100480	168828-58-8	C 16H 20FN 3O 3S
U-101387	170858-33-0	C 21H 27N 3O 3S
U-101958	170856-57-2	C 21H 29N 3O
U-103017	166335-18-8	C 28H 28N 2O 5S

參考文獻

^ Lohrstorfer, Martha; Larson, Catherine. William E. Upjohn: Person of the Century 1853 - 1932. Kalamazoo Public Library. 2002 [December 24, 2024]. （原始內容存檔於May 17, 2008）. Known by his contemporaries as a dreamer and a tinkerer, Dr. Upjohn saw a need to improve the means of administering medicine. Most medicines of the day were in fluid form, and those in pill form were often hard and insoluble. Patients were left to try to digest the bitter medicine, with no guarantee that it would dissolve in their systems effectively. Dr. Upjohn began experimenting with making better pills in the attic of his home. Eventually he invented his "friable" pill. Friable meant that the pill could easily be crushed to a powder. The pill was patented in 1885, and its reputation quickly spread within the medical community, thanks greatly to Dr. Upjohn's marketing strategy. He sent small pine boards to thousands of physicians along with samples of his rival's hard pills, and his own friable pills. He invited doctors to hammer the pills into the boards to see which one would be the most digestible. This tactic was eventually modified, but for the next 60 years, a thumb reducing an Upjohn pill to powder was used as the trademark symbol of his company, the Upjohn Pill and Granule Company, later more widely known to the world as The Upjohn Company.
^ VanRheenen, V.; Kelly, R.C.; Cha, D.Y. An improved catalytic OsO4 oxidation of olefins to -1,2-glycols using tertiary amine oxides as the oxidant. Tetrahedron Letters. 1976-06, 17 (23): 1973–1976. doi:10.1016/S0040-4039(00)78093-2.
^ ^3.0 ^3.1 ((Lyster, S C.)), ((Duncan, G W.)). ANABOLIC, ANDROGENIC AND MYOTROPIC ACTIVITIES OF DERIVATIVES OF 7α-METHYL-19-NORTESTOSTERONE. Acta Endocrinologica. July 1963, 43 (3): 399–411. doi:10.1530/acta.0.0430399. 溫哥華格式錯誤 (幫助)
^ ((Castañer, J.)), ((Hillier, K.)). U-23,469. Drugs of the Future. 1980, 5 (11): 564 [2026-02-25]. ISSN 0377-8282. doi:10.1358/dof.1980.005.11.1002363. （原始內容存檔於2022-02-28）.

外部連結

[1] Lohrstorfer, Martha; Larson, Catherine. William E. Upjohn: Person of the Century 1853 - 1932. Kalamazoo Public Library. 2002 [December 24, 2024]. （原始內容存檔於May 17, 2008）. Known by his contemporaries as a dreamer and a tinkerer, Dr. Upjohn saw a need to improve the means of administering medicine. Most medicines of the day were in fluid form, and those in pill form were often hard and insoluble. Patients were left to try to digest the bitter medicine, with no guarantee that it would dissolve in their systems effectively. Dr. Upjohn began experimenting with making better pills in the attic of his home. Eventually he invented his "friable" pill. Friable meant that the pill could easily be crushed to a powder. The pill was patented in 1885, and its reputation quickly spread within the medical community, thanks greatly to Dr. Upjohn's marketing strategy. He sent small pine boards to thousands of physicians along with samples of his rival's hard pills, and his own friable pills. He invited doctors to hammer the pills into the boards to see which one would be the most digestible. This tactic was eventually modified, but for the next 60 years, a thumb reducing an Upjohn pill to powder was used as the trademark symbol of his company, the Upjohn Pill and Granule Company, later more widely known to the world as The Upjohn Company.

[2] VanRheenen, V.; Kelly, R.C.; Cha, D.Y. An improved catalytic OsO4 oxidation of olefins to -1,2-glycols using tertiary amine oxides as the oxidant. Tetrahedron Letters. 1976-06, 17 (23): 1973–1976. doi:10.1016/S0040-4039(00)78093-2.

[Lyster-3] 3.0 ^3.1 ((Lyster, S C.)), ((Duncan, G W.)). ANABOLIC, ANDROGENIC AND MYOTROPIC ACTIVITIES OF DERIVATIVES OF 7α-METHYL-19-NORTESTOSTERONE. Acta Endocrinologica. July 1963, 43 (3): 399–411. doi:10.1530/acta.0.0430399. 溫哥華格式錯誤 (幫助)

[4] ((Castañer, J.)), ((Hillier, K.)). U-23,469. Drugs of the Future. 1980, 5 (11): 564 [2026-02-25]. ISSN 0377-8282. doi:10.1358/dof.1980.005.11.1002363. （原始內容存檔於2022-02-28）.

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